Alfredo LANZARO讲师

时间：[2020-10-20]  来源：

一、联系方式：

Alfredo.Lanzaro@gmail.com

二、教育经历：

(1) 2018-至今: 特聘讲师, 广州大学系统流变学研究所

(2) 2016-2018: Post-Doctoral Fellow, Lund University, Lund, Sweden

(3) 2011-2016: Post-Doctoral Research Associate, the University of Manchester, Manchester, UK

(4) 2007-2011: Ph.D. in Chemical Engineering, the University of Manchester, Manchester, UK

(5) 1999-2005: Master of Engineering, School of Chemical Engineering, the University of Naples, Italy

三、研究方向：

（1）Elastic Turbulence

The flow of complex fluids such as polymer solutions and colloidal dispersions through micro-fabricated devices gives rise to a variety of non-Newtonian fluid effects, such as purely elastic instabilities or even turbulence, which cannot be visualised if the same fluids move through macroscale flow geometries. In microfluidic flows, complex fluids experience rates of deformation on the order of 105 s-1 or above, hence the Weissenberg number Wi, which characterises the strength of deformation rate, becomes large, while the Reynolds number Re, characterising flow inertia, is still negligible. The high Wi, low Re flow regime observed in microscopic flows is relevant for a variety of applications, including inkjet printing, spraying and enhanced oil recovery in porous media, and constitutes a robust benchmark for the validation of advanced constitutive models. We address this fundamental research topic by means of a fully quantitative approach, including molecular characterisation, shear and extensional rheometry by means of a prototypical “Rheo-chip” technology, and particle-image velocimetry (PIV).

（2）Protein Solutions Interactions and Rheology

Dense suspensions of monoclonal antibodies (Mabs) are becoming increasingly popular in threating a large amount of diseases, including respiratory deficiency, arthritis and various forms of cancer. In order for a Mab-based drug to be effective, active protein concentrations on the order of 100 g/L or above must be achieved, which leads to notable viscosity enhancement. Moreover, many industrial and healthcare operations involving Mab dispersions (i.e. sub-cutaneous injection, tangential flow filtration, vial filling) feature inherently high shear rates (104 s-1 or above), where non-Newtonian flow effects, such as viscoelasticity and shear thinning, are typically observed.  Understanding the link between the type and strength of the protein-protein interactions and the rheological behaviour of dense biopharmaceutical solutions is of paramount importance for industry. We address such fundamental question by means of a combination of molecular (static and dynamic light scattering, neutron scattering) and rheometric techniques (Rheo-chip in steady and oscillatory mode).

（3）Colloidal Molecules in Microfluidics

“Colloidal molecules” are a class of building blocks characterised by specific and highly directional interactions, which mimic phenomena typically occurring at the molecular level. The assembly of colloidal molecules in more complex structures resembling natural formations (i.e. viral shells) is highly dependent on a variety of parameters, including temperature, pH, ionic strength and presence of electric fields. In order to map out the rich phase behaviour of this novel class of materials, we employ a microfluidic “phase chip” technology which allows for fast quantitative screening of the behaviour of colloidal particles under different field conditions.

四、研究合作伙伴：

European Horizon 2020: Protein-excipient Interactions and Protein-Protein Interactions in formulation (PIPPI) - Concentrated Solution Rheology (hosted at Manchester Institute of Biotechnology, the University of Manchester, UK)

The European Research Council (ERC): Colloids with Complex Interactions (COMPASS) - from model atoms to colloidal recognition and bioinspired self assembly (hosted at Lund University, Lund, Sweden)

五、代表性学术论文：

[1] A. Lanzaro, “Microscopic Flows of Semi-Dilute Polymer Solutions”, Ph.D. thesis, the University of Manchester, 2011.

[2] A. Lanzaro and X-F. Yuan, “Effects of Contraction Ratio on Non-linear Dynamics of Semi Dilute, Highly Polydisperse PAAm Solutions in Microfluidics”, Journal of Non-Newtonian Fluid Mechanics, 166, 1064-1075, 2011.

[3] A. Lanzaro and X-F. Yuan, “A quantitative analysis of spatial extensional rate distribution in nonlinear viscoelastic flows”, Journal of Non-Newtonian Fluid Mechanics, 207, 32-41, 2014.

[4] A. Lanzaro and X-F. Yuan, “Quantitative characterization of high molecular weight polymer solutions in microfluidic hyperbolic contraction flow”, Microfluidics and Nanofluidics, 18, 819-828, 2014.

[5] A. Lanzaro, D. Corbett and X-F. Yuan, “Quantitative characterization of high molecular weight polymer solutions in microfluidic hyperbolic contraction flow”, Journal of Non-Newtonian Fluid Mechanics, 242, 57-65, 2017.

[6] M. Shah, D. Corbett, A. Lanzaro, A. Roche, N. Sibanda, P. Davis, S. Uddin, C. F. Van der Walle, R. Curtis and A. Pluen, “Micro- and macro-viscosity relations in high concentration antibody solutions”, European Journal of Pharmaceutics and Biopharmaceutics, 153, 211-221, 2020.

[7] A. Lanzaro, A. Roche, N. Sibanda, D. Corbett, P. Davis, M. Shah, J. A. Pathak, S. Uddin, C. F. van der Walle, X-F. Yuan, A. Pluen and R. Curtis, “Cluster Percolation Causes Shear Thinning Behaviour in Concentrated Solutions of Monoclonal Antibodies”, Molecular Pharmaceutics, 18, 7, 2669–2682, 2021.

[8] A Lanzaro, “A Microfluidic Approach to Studying the Injection Flow of Concentrated Albumin Solutions”, SN Applied Sciences, 3:783, 2021.

[9] A. Lanzaro and L. Gentile, “Rheology of Active Fluids”, in “Out-of-Matter Equilibrium Soft Matter: Active Fluids”, the Royal Society of Chemistry, 2022.

[10] A. Lanzaro and X-F. Yuan, “A Microfluidic Prototype for High-Frequency, Large Strain Oscillatory Flow Rheometry”, Micromachines, 2022, 13, 256.

[11] Fan, Y.-Q., Lanzaro, A., and Yuan, X-F., “Universal concentration scaling on rheometric properties of polydisperse and high molecular weight polyacrylamide aqueous solutions”, Chinese Journal of Polymer Science, 2022. Accepted.

六、非同行评审：

Yuan, Z.-F., Odell, J., Li, Z., Lanzaro, A., Omowunmi, S., Haward, S., Yeates, S., Booth, C., and Kamp, A. “Quantitative Characterization of Complex Fluids in Microfluidics”, AIP conference proceedings, 2008.

七、会议会谈：

December 2020. “The Effects of Weak Protein-Protein Interactions on Non-Linear Rheometry of Dense Solutions of Monoclonal Antibodies”, 18th International Conference on Rheology, Rio de Janeiro, Brazil (online event).

August 2019.  “A Quantitative Study on the Effects of Interfacial Viscoelasticity on Droplet Coalescence Dynamics”, Chinese Congress of Theoretical and Applied Mechanics (CCTAM), Hangzhou, China.

August 2019.  “Macromolecular Dynamics of High Concentration Protein Solutions in Microfluidics”, Chinese Congress of Theoretical and Applied Mechanics (CCTAM), Hangzhou, China.

June 2018.  “Role of Protein-Protein Interactions in Non-Linear Rheometry of Dense Solutions of Monoclonal Antibodies”, the 2018 Pacific Rim Conference on Rheology, Jeju, South Korea. Keynote Lecture

April 2017. “A Rheo-Chip Platform for Microfluidic Rheometry of Complex Fluids”, the 26th Nordic Rheology Conference, Copenhagen, Denmark.

March 2017. “Investigating Injectability of Concentrated Protein Solutions”, CPI Analytical Meeting, Darlington, UK.

October 2015.  “A Syringe-on-Chip Device for Quantitative Injectability Study of Concentrated Protein Solutions”, the 87th Society of Rheology Meeting, Baltimore, USA.

August 2012.  “Quantitative Flow Characterisation of Aqueous PAAm Solutions in Microfluidics”, the 17th International Congress in Rheology, Lisbon, Portugal.

May 2009.  “Towards a novel design of Microfluidic Rheometer”, the 5th Meeting of the European Society of Rheology, Cardiff, UK.

December 2008.  “Quantitative characterization of complex fluids in highly non-linear flow regimes”, British Society of Rheology Midwinter Meeting, 2008, Leeds, UK.

八、专利：

1. A significant contribution has been given to the work discussed in Yuan, X-F., “Rheometry Apparatus”, US Patent, 13/813,933, 2011.

2. Yuan, X-F., Yuan, S., Lanzaro, A. and Zhang, S., “A Device for Efficient Esfoliation of 2D Materials under Low Reynolds Number”, Chinese Patent Z. L. 2019 2 0423168.1.